Each pill contains

Active Ingredients	Amount
Folic acid	200 میکروگرم
L-methyl folate	208 میکروگرم
Iodine	150 میکروگرم
Vitamin B1	1.2 میلی‌گرم
Vitamin B2	1.6 میلی‌گرم
Vitamin B5	6 میلی‌گرم
Vitamin B6	1.9 میلی‌گرم
Vitamin B12	3.5 میلی‌گرم
Vitamin E	19.5 میلی‌گرم
Biotin	60 میکروگرم
Niacin	15 میلی‌گرم
Vitamin C	110 میلی‌گرم

Each capsule contains

Active Ingredients	Amount
Docosahexaenoic acid (DHA)	200 mg
ویتامین E	18 mg

One tablet and one capsule daily from the 13th week of pregnancy until the end of breastfeeding or as directed by the doctor.

Packaging and Dosage Form:

Each box has 30 tablets and 30 capsules with a patient information leaflet.

Therapeutic and pharmacological effects:

During pregnancy, the body’s need for essential nutrients increases to support the growth and development of the fetus. Meeting these requirements through diet alone can be challenging, and taking supplements is an effective way to ensure maternal and fetal health.

Key Components in Pregbion ^® 2:

DHA (Docosahexaenoic Acid):

DHA is a vital omega-3 fatty acid essential for the development of the brain and retina.

During the last trimester, DHA accumulates in the rapidly developing fetal brain, concentrating in gray matter and retinal membranes.

Adequate maternal intake of marine-derived omega-3 fatty acids may reduce risks of inflammatory-related conditions, such as preterm delivery, preeclampsia, and allergic diseases in children.

Iodine:

Crucial for producing thyroxine (T4) in the mother, which the fetus relies on for normal brain development early in pregnancy.

Deficiency in iodine can lead to irreversible brain damage in the fetus.

The American Thyroid Association recommends a daily supplement containing 150 mcg of iodine for pregnant women.

Folic Acid:

Essential for preventing neural tube defects, low birth weight, and miscarriage.

It is recommended to begin supplementation before pregnancy and continue throughout to prevent congenital abnormalities.

B Vitamins:

Vitamin B12 deficiency can impair fetal growth and lead to long-term neurological damage.

Low levels of B vitamins are associated with recurrent miscarriages, preterm birth, and low birth weight.

Vitamin C:

Acts as an antioxidant, protecting tissues from free radicals and reducing oxidative stress, a factor in conditions like preeclampsia.

Studies indicate its role in improving fertility and possibly boosting reproductive outcomes.

Vitamin E:

Known for its antioxidant properties, Vitamin E supports reproductive health and combats age-related changes in the placenta.

Regular intake is especially recommended for women of reproductive age.

Pregbion^® 2 combines these essential vitamins and minerals, along with DHA capsules, to support the health of both mother and baby from the fourth month of pregnancy through breastfeeding.

Side effects:

Severe allergic reactions to this product are rare. Symptoms may include skin rashes, redness and inflammation of the skin, itching, weakness, and bronchospasm.

Other side effects may include diarrhea, nausea, vomiting, metallic taste in the mouth, heartburn, abdominal pain, hives, fatigue, drowsiness, insomnia, headache, runny nose, blurred vision, and flushing.

Drug interactions:

Iodine may interact with lithium, amiodarone, and antithyroid medications, as these drugs can alter iodine levels.

Folic acid can interact with methotrexate, phenobarbital, primidone, and pyrimethamine.

High doses of vitamin E combined with anticoagulant medications may increase the risk of bleeding.

If you are taking other supplements or medications, consult your physician or pharmacist before use.

DHA may interact with:

Anticoagulant medications: It can reduce the effectiveness of anticoagulants and increase the risk of bleeding.

Antidiabetic medications: It may increase fasting blood sugar levels in diabetic individuals.

Antihypertensive medications: It can enhance the effects of blood pressure-lowering drugs.

Warnings and precautions:

If you have an autoimmune thyroid disorder, consult your physician before using this product.

Contraindications:

Avoid using this product in the following cases:

Allergy to any of its components.

Concurrent use of hyperthyroidism medications, including methimazole, propylthiouracil, potassium iodide, or radioactive iodine (sodium iodide I-131).

Pregnancy and breastfeeding:

This product is recommended from the time of deciding to conceive until the end of the twelfth week of pregnancy.

It is recommended to use this product from the fourth month (13th week) of pregnancy until the end of breastfeeding.

Storage conditions:

Store at a temperature below 25°C, away from light, moisture, and out of reach of children.